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221 W Saint Joseph Street

221 W Saint Joseph Street

Perryville, MO 63775

For Sale MLS# 25081439 144 days on market

$560,000

$178 / sq ft

6

Bedrooms

4.5

Bathrooms

3,143

Sq Ft Above Grade

0.37

Acres

About This Home

Looking for a turn key, fully operational business in the heart of Perryville? The Mediterranean House presents a rare opportunity to own a luxury property designed to host unforgettable stays and events. Currently operating as a successful and versatile venue, this property is well suited for use as an Airbnb, bed and breakfast, or a destination for corporate retreats, wellness or yoga getaways, and private events. The home features six beautifully appointed bedrooms, four full bathrooms, and one half bathroom, offering ample accommodations for guests. A commercial grade kitchen equipped with stainless steel appliances is ready to support culinary experiences, from baking and cooking workshops to catered events. All furniture stays, including antique furnishings, bedroom suites, dining room suites, etc. With its flexible layout and elegant setting, The Mediterranean House is ideal for bridal and baby showers, birthday celebrations, intimate gatherings, or larger hosted events. This is a truly turn key business opportunity, ready for immediate operation, offering the space, functionality, and charm to bring a wide range of visions to life.

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Property Details

MLS#25081439
StatusFor Sale
Property TypeResidential
Property Sub-TypeSingle Family Residence
Year Built1910
Bedrooms6
Bathrooms Full4
Bathrooms Half1
Sq Ft Above Grade3, 143
Lot Size Acres0.37
Lot Dimensions73x7x171x68x134x12x318
SubdivisionFifth Principal Meridian
Fireplaces3
Annual Taxes$4, 078 (2025)
Elementary SchoolPerryville Elem.
Middle SchoolPerry Co. Middle
High SchoolPerryville Sr. High

Listing History

Listed: December 16, 2025 (144 days on market)

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